This bypasses the gastrointestinal tract, which can be beneficial as it avoids the first-pass metabolism in the liver, potentially increasing the bioavailability of glutathione
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Functional compensation of glutathione S-transferase M1 (GSTM1) null by another GST superfamily member, GSTM2
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doi: 10.1016/j.jad.2012.02.018 154 OneilAQuirkSEHousdenSBrennanSLWilliamsLJPascoJAet al
98,99 Then, the hydrophobic C-terminal of AMP may insert into the hydrophobic region of the cell membrane, which may change the conformation of the cell membrane and reduce the activity of P-gp by inhibiting the efflux of chemotherapy drugs, increasing the intracellular drug concentration, and reversing drug resistance of MDR tumor cells